ROGER Federer cruised into the US Open quarter-finals, thrashing 15th seed David Goffin 6-2 6-2 6-0 in just 78 minutes.The Swiss five-time champion fell a break down early in the first set but then won six games in a row to establish control in the fourth-round match.Federer, 38, hit 34 winners while Belgian Goffin could only manage eight.He will face Bulgarian Grigor Dimitrov in the last eight.Dimitrov, a former world number three whose ranking has dropped to 78, beat Australian Alex de Minaur 7-5 6-3 6-4.Federer said of his win: “It was great. David didn’t have his best day either, he was struggling. I was down on the score early so had to come back mentally.“But then when I was up a break I started to feel like he wasn’t playing the same way and I was very happy with my level of play.”The third seed had dropped the first sets in both of his opening two matches, but played with a swagger when he beat British number two Dan Evans in 80 minutes in the last round.That form continued against Goffin, with the Belgian winning less than half Federer’s total of 83 with 39.Federer booked his place in the quarter-finals for the 13th time in New York with a stunning passing shot down the line and remains on course to face world number one Novak Djokovic in the semi-finals – a rematch of the epic Wimbledon final which the Serb won in a fifth-set tie-break.And should Federer make it to the last day for the first time since his defeat by Djokovic in 2015, he could come up against Spanish second seed Rafael Nadal for the first time at the US Open in the final. (BBC Sport).
The Confederation of African Football (CAF) has dismissed Egyptian Amr Fahmy from his role as general secretary, BBC Sport Africa understands.CAF’s Executive Committee made its decision in Cairo on Thursday ahead of the draw for the 2019 Africa Cup of Nations.The reason for the dismissal is unclear as CAF has yet to comment. Fahmy was appointed in November 2017 as he followed in the footsteps of his father and grandfather.Fahmy’s grandfather Mourad served as general secretary of African football’s governing body from 1961-1982.Mourad was replaced by his son Mustapha, who held the post until 2010 before being appointed as the director of competitions at FIFA.Morocco’s Mouad Hajji, who was appointed as CAF’s general coordinator role earlier this year, is being tipped to replace Fahmy.On Friday, the 24 finalists at this year’s Nations Cup will discover who they will play when the tournament gets underway in June.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Amr Fahmy
New York University and USC have collaborated to create a breakthrough project in cancer treatment. Together, they have developed a new synthetic molecule that will disrupt the “conversation” between cancer cells in the human body.According to a press release, the synthetic molecule created targets the interaction between two proteins, causing the genes to promote tumor progression. This compound was specifically designed to interrupt the type of molecular conversation within the cell that promotes the growth of cancer cells and tumor progression. The NYU team is lead by chemistry professor Paramajit Arora, and the USC team is led by the USC School of Pharmacy professor Dr. Bogdan Olenyuk.“Professor Paramjit Arora and I studied together at Caltech,” Olenyuk said. “He is an expert in bioorganic chemistry and chemical biology, specifically in the design of synthetic protein mimetics, and we have been working on this project since 2007.”HBS1, the synthetic molecule described in their paper, limits tumor progression. The method required for locking the correct spiral helical shapes in synthetic strings of amino acids was developed at NYU.“Our designed compound selectively disrupts expression of genes required for tumor progression and metastasis,” Olenyuk said.The results from this research project could be tremendously important for the future in the scientific community.“These results could dramatically improve several types of cancer therapies currently used in the clinic,” Olenyuk said.Dr. Ramin Dubey, a member of Olenyuk’s team, who worked toward the development of small molecule therapeutics that targets angiogenesis, or formation of new blood vessels in tumors, was involved in development of two classes of molecules.“Our approach works on transcriptional level of cancer progression by inhibiting the transcription factor HIF-1,” Dubey said. “Inhibiting the transcription factors directly is, in theory, a very powerful approach but not many practical examples are known for this strategy. Our work is a significant step in showing the practical relevance of this approach.”Dr. Swati Kushal, a USC School of Pharmacology postdoctoral scholar, also contributed to the project by exploring the biological potential of the rationally designed compounds that can selectively disrupt the a transcription factor complex and hence down-regulate the expression of genes critical for tumor progression and metastasis.“Our research has demonstrated the potential of designed protein secondary structure mimetics to become new research tools for disruption of protein-protein interfaces involved in transcription factor complex,” Kushal said.The work will likely revolutionize the cancer treatment drug creation process.“Of all the proteins in cells, less than 20 percent are considered as druggable,” Kushal said. “With the innovative approaches in hand, I would hope that it would be possible to raise this bar that would ultimately lead to the discovery of novel therapeutics.”USC researcher Hanah Mesallati was involved in maintaining the cancer cell lines and carrying out in vitro cell-based assays, including viability and luciferase studies.“The results of this research show that transcription factor protein domain mimetics can halt the growth of tumors in vivo,” Mesallati said. “Hopefully this research will eventually lead to the development of pharmaceutical agents, which will form part of an effective multi-drug chemotherapy regime.”Follow us on Twitter @dailytrojan
Grade Syracuse’s performance against Florida StateABCDFVoteView ResultsCrowdsignal.comGrade Syracuse's performance against Florida State Facebook Twitter Google+ Published on February 11, 2016 at 9:03 pm AdvertisementThis is placeholder text Comments
Arsenal midfielders Emmanuel Frimpong and Jack Wilshere have returned to first-team training.Wilshere, 20, injured his ankle in a pre-season friendly in August 2011 and missed the whole of the 2011-12 season. He suffered a setback in his recovery in January and then had to have knee surgery in May.“It’s been 14 months and that’s a long time for someone at his age,” said Arsenal manager Arsene Wenger. “It’s an eternity, but it’s great news.”He added: “We have to give him a few training sessions to see how he copes and responds to it.“That’s the delicate, sensitive stage – to choose when to bring him in and out. We’ll have to handle that day by day.” Frimpong suffered an anterior cruciate knee ligament injury in February while on loan at Wolves.Wenger told the club website: “We also have Emmanuel Frimpong who has returned to full training this week, which is great news as well.“Emmanuel has also been out a long time, but is progressing well.”
The hospital said Pele was in a “good condition” in terms of blood pressure and the respiratory system, and continues to receive antibiotics intravenously.Pele has had only one kidney since his playing days, when one was removed after complications from a rib broken while playing. The hospital did not say when Pele could leave the hospital although his son, former player Edinho, said it could happen by the end of the week. He was hospitalised on November 24 after being diagnosed with a urinary tract infection that stemmed from a surgery to remove kidney stones. Recent tests have shown no signs of the infection. Pele has been taken off intensive care as his condition continues to improve after the three-time World Cup winner was transferred to the hospital five days ago for kidney support treatment.The 74-year-old is now under “semi-intensive” care, the Albert Einstein Hospital said in a statement.”Pele is getting better,” he was “lucid, eating well” and has been “walking around” the room, the hospital added.
Portland coach Terry Stotts had warned of such an effect before the game.“NBA players have a lot of pride,” he said, “and when you get beat that badly, you expect a really good effort the next time.”Wins have been tough for the Lakers to come by in the last four years, but especially against Portland. The Lakers have now lost 11 straight against the Blazers, dating back to March 3, 2014. On a historical note, it is the fourth-longest losing streak by the Lakers against any team. On a rare night that both Mitch Kupchak and Jim Buss were both in attendance on the road, a sincere effort was made to put an end to that dubious distinction.Ivica Zubac logged his second double-double, finishing with 12 points and 10 rebounds while Jordan Clarkson added 22 points off the bench.However, the Lakers starting backcourt was no match for the Portland pair of Damian Lillard and C.J. McCollum. Those two combined for 48 points, while Jose Calderon was held scoreless and Nick Young scored 15 points, but only eight after the first six minutes of the first quarter. They pulled even at 94 on a 3-pointer by Nick Young with 6:23 remaining in the game, and then Young gave the Lakers the lead 42 seconds later on another 3.It proved to be short-lived, as the Lakers scored just four points the rest of the game, and went meekly home. The Lakers brief lead temporarily answered a challenge set forth by coach Luke Walton over the course of a long plane ride, two practices and a shoot around following Sunday’s loss in Dallas, the largest in Lakers franchise history.“Try to get (in) the mindset of how we need to play going forward,” Walton said. “(I) hope that the guys still aren’t dwelling on it, but hope that they’re still (ticked) off about it. Which is a fine line. We need to come out and play with an edge.”The Lakers led 31-30 after the first quarter and trailed 59-58 at halftime. On a night Bill Walton and the championship Blazers of 1977 were honored, it looked like the Lakers might actually put the brakes on their dismal track record against the Blazers. PORTLAND, Ore. >> The Lakers seem intent on experiencing losing in all of its cruelest forms.After having three days to rebound from a 49-point blowout loss in Dallas, the Lakers wasted a fourth-quarter lead, falling to the Portland Trail Blazers 105-98. Basketball is cruel. Especially to a certain team from Los Angeles.After trailing by as many as 14 points in the third quarter of a game they had trailed by only one at halftime, the Lakers (16-32) crawled back behind 11 quick points from Lou Williams, who scored a game-high 31 points. Newsroom GuidelinesNews TipsContact UsReport an Error
The teams the Steelers are battling with are the Broncos (8-6), Ravens (8-6), Jaguars (7-7), Dolphins (7-7), Jets (7-7), Texans (7-7) and Titans (7-7).The Ravens looked impressive as they easily defeated the Bears 31-7 to stay ahead of the Steelers and make this weekend’s showdown at Heinz Field enormous for both teams. This has become one of the biggest rivalries in the NFL and no game has been bigger for these two teams than this weekend, which will just about eliminate the loser. Who knows, maybe all the other contenders will lose, again.The Dolphins have been one of the hottest teams in the league of late but they ran into an even hotter team in the Titans and went down to a 27-24 overtime loss. The Titans after starting 0-6 with Vince Young on the bench having gone 7-1 since the owner forced the coach to start him. This is a team no one wants to see in the playoffs.The Steelers almost had their typical fourth quarter meltdown as the Packers came roaring back to take a 36-30 lead with only minutes left, after outscoring the Steelers 22-6 in the fourth quarter to that point. The offense put together one of its most impressive drives of the season, a 12- play, 86-yard drive, ending with the sensational 19-yard touchdown reception by Mike Wallace from Roethlisberger that looked a lot like the play in which Santonio Holmes helped win the Super Bowl. The Steelers ended the game much like they began, with a touchdown pass to Wallace. They opened the game with a 60-yard strike to Wallace who outran his defender, but still had to come back for the under thrown ball for the touchdown. He only had two catches in the game, both for scores.“He made plays when given the opportunity, not that he’s had a bunch of opportunities and sometimes, it’s like that,” said coach Mike Tomlin. “It’s about what you do with them when you get them. He played big. He played older than a rookie for us today which was needed.”It took the best game of the season from Roethlisberger for the Steelers to pull it off. The defense faltered, and Tomlin decided to try an on-side kick, that failed, deep in Packer territory, which led to a Green Bay score that most thought was the game.The 503 yards racked up by Roethlisberger was a Pittsburgh record. He was 29 of 46 with three touchdown passes. The running game was all but abandoned with Rashard Mendenhall picking up 38 yards on just 11 carries and Willie Parker 22 yards on just six carries. However, Mendenhall was very active in the passing game as he had six receptions for 73 yards. Of the six players grabbing those 503 yards, Hines Ward led the way with seven catches for 126 yards, which put him over 1,000 for the year for the sixth time in his career; Heath Miller had seven catches for 118 yards, a personal best, and he also broke the record for tight end receptions for a single season. Holmes had three catches for 77 yards.Aaron Rodgers, who’s rapidly becoming one of the brightest young quarterbacks in the league, picked the Steelers defense apart for 383 yards on 26 of 48 passing and three touchdowns. Young Greg Jennings had eight catches for 118 yards, including an 83 yard touchdown catch that erased the 60-yarder by Wallace, pulling the Packers even, and tight end Jermichael Finley had nine catches for 74 yards. The defense held running back Ryan Grant to just 37 yards on eight carries.Once again the defense looked weak, primarily the secondary with rookie Joe Burnett playing in place of William Gay. It would be hard to play any worse than Gay has in the past eight games.The win ended the Steelers five-game losing streak Right now the Indianapolis Colts (14-0), San Diego Chargers (11-3), Cincinnati Bengals (9-5), and New England Patriots (9-5) pretty much have the divisions sewn up. Only the Bengals could possible fall, if they lose both of their remaining games and the Ravens win both of theirs. Stranger things have happened, especially when dealing with the Bengals. The Steelers were able to avoid a fourth quarter collapse to keep their slight glimmer of a playoff birth alive with a last second touchdown pass from Ben Roethlisberger to Mike Wallace giving them a thrilling 37-36 victory over the 9-5 Green Bay Packers. Now they must prepare for conference rival Baltimore (8-6).With the Miami Dolphins, New York Jets, Jacksonville Jaguars and Denver Broncos all losing, the Steelers stayed alive, but they will have to win out against the Ravens and the Dolphins, and hope the teams ahead of them for the wild card berth continue to lose. PLAY OF THE GAME— Pittsburgh Steelers receiver Mike Wallace catches a touchdown pass from quarterback Ben Roethlisberger in front of Green Bay Packers’ Josh Bell (26) with time running out in the fourth quarter Dec. 20, in Pittsburgh. The Steelers won 37-36.
Saturday, Oct. 6Stephen F. Austin vs. Sam Houston State, 1 p.m. CT, ESPN3*Southeastern Louisiana at Incarnate Word, 4 p.m. CT, UIW Stretch Internet PortalNicholls at Northwestern State, 6 p.m. CT, Cox Sports TVAbilene Christian at McNeese, 6 p.m. CT, Cowboy InsiderHouston Baptist at Central Arkansas, 6 p.m. CT, Bear Nation Network*at Houston’s NRG Stadium FRISCO, Texas – The Southland Conference and its broadcast partners have revealed game selections and start times for football games to be played on Saturday, Oct. 6. While choices for the first four weeks of the regular season were completed during the summer, picks are made 12 days prior to kickoff for the remaining weeks.ESPN3 will feature the 93rd Battle of the Piney Woods, as Sam Houston State faces Stephen F. Austin at Houston’s NRG Stadium. The series ranks as the longest running NCAA Division I FCS rivalry in Texas and has seen the Bearkats win seven conseuctive meetings.Cox Sports Television is set to provide regional coverage of Nicholls at Northwestern State. ESPN3 will simulcast the production outside CST’s territory.The day’s other three games will be streamed via institutional productions.
Bale left Spurs in the summer of 2013 for a then-world record £85million fee – months after Mourinho left the Bernabeu for Chelsea.He still has a contract in the Spanish capital until the summer 2022.In the summer, the 30-year-old was close to completing a sensational move to CHINA – but the plug was pulled by the Real Madrid board.Gareth Bale ‘in contact’ with Mourinho over shock return to Tottenham which could see Eriksen transfer to Real Madrid MAKE YOUR DEBUT Bet £5 get £20 in free bets for new customers at Ladbrokesmost read in footballTHROUGH ITRobbie Keane reveals Claudine’s father was ’50-50′ in coronavirus battleTOP SELLERGavin Whelan has gone from League of Ireland to David Beckham’s InstagramPicturedAN EYEFULMeet Playboy model and football agent Anamaria Prodan bidding to buy her own clubExclusiveRIYAD RAIDMan City’s Riyad Mahrez has three luxury watches stolen in £500,000 raidI SAW ROORodallega saw Rooney ‘drinking like madman’ & Gerrard ‘on bar dancing shirtless’NEXT STEPJonny Hayes set to move to English Championship having been let go by CelticREF RELEASEDChampions League ref Vincic released by cops after arrest in prostitution raidKEANE DEALEx Man United youth ace David Jones says Roy Keane negotiated a contract for himREF RAIDChampions League ref Vincic ‘arrested in raid into drugs and prostitution ring’NICE RONCristiano Ronaldo goes on family bike ride with partner Georgina Rodriguez & kids TOTTENHAM are not close to sealing a sensational return for Real Madrid winger Gareth Bale, SunSport understands.Jose Mourinho’s side have been linked with a high-profile move for the Welshman before tonight’s transfer deadline.1 Gareth Bale’s wage demands remain the biggest issueCredit: Getty – ContributorReports suggest the two clubs have held talks with Bale still on the fringes of Zinedine Zidane’s first team.The Times write how chairman Daniel Levy has travelled to Madrid for talks with club president Florentino Perez.SPURS NEWS LIVE: Follow all the latest news on TottenhamBut Bale would need to agree to take a huge pay cut as he currently pockets a staggering £600,000-a-week wage.Spurs already have a strict wage structure and a deal to sign Bale would completely smash their salary policy.Any deal is likely to be on loan with a view to a permanent move but Bale’s wage demands just add to the complications of the deal.Zidane was quizzed on the possibility of letting Bale leave today but insisted he is not “contemplating him leaving”.The Frenchman said: “Gareth is here with us and I am counting on him. I am not contemplating this possibility.”